Both Haemophilia and Thalassemia are blood related disorders in humans. Write their causes and the difference between the two. Name the category of genetic disorder they both come under .

Kajal Chauhan · 12th May 2019 .

Kumar Soren · 12th May 2019 .

16. Haemophilia is genetically due to the presence of a recessive sex linked gene h, carried by X-chromosome. Thalassemia is caused due to mutation or deletion of gene controlling formation of globin chains of haemoglobin.

Haemophilia is a sex-linked recessive disorder and thalassemia is an autosomal linked recessive disease. Both haemophilia and thalassemia are Mendelian disorders.

Differences between thalassemia and haemophilia is as follows:

	Haemophilia	Thalassemia
(i)	Sex-linked recessive disorder.	Autosomal linked recessive disorder.
(ii)	Occurs due to presence of sex linked gene h carried by X-chromosome.	Occurs due to mutation or deletion of genes controlling formation of globin chains of haemoglobin.
(iii)	Follows criss-cross inheritance.	Inheritance is straight from both the parents to all the offspring.
(iv)	Due to absence of anti-haemophiliac globulin and plasma t hromb op l a s t in factor IX, the blood does not clot and patient continue to bleed even from a minor cut.	There is reduced synthesis of either a or b chains of haemoglobin which causes anaemia, jaundice, hepatosp- lenomegaly, cardiac enlargement and skeletal deformities.

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